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Abstract

The most widely used drugs for prophylaxis and treatment of CMV infections are chemical drugs. Unfortunately, these drugs have dose-limiting renal and bone marrow toxicities. Also, the long-term therapy with these necessary for management of infection, has been associated with the development of clinically resistant strains of the virus.

Therefore, antiviral agents would need to develop for the treatment and suppression of CMV disease. Natural products of plant origin are proving to be a valuable source for anti-viral agents. So, the aim of the current study was to in vitro of Allium sativum and Nigella sativa methanolic extracts as anti-CMV agents. Murine Embryonic Fibroblasts (MEFs) were infected with CMV and propagative, plaque assay of CMV titer was 9.5x106 (PFU/ml) at four days post infection. Two methanolic plants extracts showed anti-cytomegalovirus (CMV) activity against CMV tissue culture which determined by cytopathic effects whereby, the number of staining survival cells were increased with the treatment by A. sativum or N. sativa methanolic extracts. While a mixture of both extracts showed a synergistic effect in controlling the virus greater than each extract in a solo state.

Source: http://article.sapub.org/10.5923.j.microbiology.20180802.02.html