Author: by Bence Zsoldos

Title: Bile acid and GALLMET study 2013
Source: https://pubmed.ncbi.nlm.nih.gov

About the cholesterol problem

Cholesterol is an essential compound for all animal organisms, so its absence is incompatible with life. This is why almost all cells are able to synthesise this molecule of four rings and side chains from two carbon atoms.
Cholesterol is used by different organs, sometimes with only slight modification, to produce compounds with very different effects, collectively known as steroids. These include male and female sex hormones, adrenal hormones that regulate carbohydrate and mineral turnover, vitamin D3 and bile acids.
The adrenal cortex produces cholesterol, a group of hormones known for their anti-inflammatory effects, known as cortisol, which is the base material for many anti-inflammatory drugs.
The large group of compounds formed from cholesterol are bile acids. These are produced by the liver. In addition to their role in the digestion and absorption of fats, they are an important aid in detoxification.
Low bile acid secretion can be the source of many diseases.
The reason for the low bile acid production is that we eat little food that forces the liver to secrete bile. The effect of low bile levels is that excess cholesterol remains in the body, the digestion of fats becomes imperfect, the absorbed fats increase the cholesterol and triglyceride content of the blood, which in turn are deposited in the bloodstream on the walls of blood vessels, narrowing their inner lumen, which can lead to circulatory problems and heart attacks.
If there is not enough bile acid in the gut, for example because we do not eat enough bile-secreting foods such as fat or oil, then the absorption and utilisation of fat-soluble vitamins (A, D, E, K) is impaired. In other words, in such a situation, even if we take the vitamins in vain, the body will be deficient due to lack of absorption.
Their primary role is to help the body get rid of excess cholesterol, which can be harmful.
High cholesterol
When the liver produces and secretes less bile acid, less bile is produced. This leaves more excess cholesterol in the body, the digestion of fats becomes more imperfect and the resulting absorbed fats increase the cholesterol and triglyceride content of the blood, depositing in the circulatory system on the walls of blood vessels, narrowing their internal lumen and thus creating catastrophic circulatory and infarct-causing situations.
Bile acids, which also circulate in the blood, help to deliver vitamins to their destination in the cells.
Two thirds of the bile acids that enter the intestine are reabsorbed into the blood and then enter the liver, where they participate in the gut-blood-liver-intestinal cycle, thus fulfilling their physiological functions.
Bile acids that pass down into the last part of the small intestine are the main factor in triggering the normal defecation stimulus.
Consequently, if little bile acid enters the small intestine, i.e. if concentrated bile is not regularly emptied from the bladder every day, constipation may occur
High levels of HDL cholesterol are beneficial because they allow cholesterol deposited in fat droplets in the walls of blood vessels to be transported back from the vessel wall to the liver, where it is broken down and excreted as outlined earlier.
Blood cholesterol levels can be high in people with poor diet, diabetes or reduced thyroid function, kidney disease and atherosclerosis
HDL cholesterol levels can be raised through proper diet and exercise. .Low HDL levels occur in 30% of men and 20% of women .Alcohol raises HDL levels in small amounts. In women, hormone replacement after the age of change raises HDL cholesterol. Vitamin B3 also raises good cholesterol. To this end, regular consumption of chicken, mackerel, trout, salmon, peanuts and veal is particularly recommended According to a study published in the journal Nature Medicine, cholesterol actually increases the production of an important neurotransmitter that facilitates proper nerve cell communication and delays the progression of brain diseases (such as Parkinson's and Alzheimer's).
Men with low or normal cholesterol levels were more likely to suffer from Parkinson's disease than their counterparts with high levels Research suggests that only one per cent of the human population carries the genes to stay healthy regardless of food, stress and other influences. A good example is the former British Prime Minister Winston Churchill, who fought a world war, never exercised, but smoked cigars and never drank alcohol, and lived to be ninety-four.