If age, lifestyle, diet, hereditary factors, disease, pregnancy (e.g. the fetus pushing on the digestive organs, their function may change), etc. If this process is physiologically malfunctioning, altered or broken, digestive problems may occur: bloating, constipation, diarrhoea, right rib-arch pain, or pain in the back, stabbing sensation, etc. Women are about twice as likely to be affected as men. In women, increased stress due to a more sensitive nervous system is usually a factor, because the "valve" for the passage of bile from the gallbladder, the sphincter of Oddi, does not open properly more often due to stress, and thus the bile gets trapped in the gallbladder, it can become thickened and lead to gallstones and digestion becomes incomplete.

Soft, cholesterol stones smaller than about 15 mm can be dissolved with GALLMET.

If the intestines do not receive sufficient amounts of bile acid, the lipopolysaccharides from the cell wall of dead gram-negative bacteria, i.e. endotoxins (internal toxins), are not properly neutralised and the endotoxins, which are not properly neutralised, can trigger inflammation in other organs via cytokines, which over time leads to disease, the cause of which is often not adequately revealed by the process analyses described above, so that the true cause of some diseases may remain unknown, and therefore symptomatic rather than causal treatments may be used.

The GALLMET food supplements contain natural bile acids (and herbs) and are able to compensate and alleviate bile circulation disturbances by supplementing bile acids on a causal basis, so that the acid-resistant aka intestinosoluble capsules only act in the duodenum where the bile duct is connected, so that the active substance in the GALLMET capsules does not enter the stomach.

After gall bladder surgery, bile flows out as there is no gall bladder, although the liver and bile ducts can store small amounts of bile. However, during (main) meals, possibly over-feeding - when there is a lot of food in the stomach - depending on the fat and partly protein content of the food, the bile flow may not be sufficient to break down fat and protein, which can lead to digestive problems, which can be compensated for by, for example, supplementing bile acid and thus helping the bile to circulate. Of course, diet and herbs can be used to balance this to a certain extent and depending on the individual, but they cannot usually neutralise endotoxins in the gut, because this requires, in the first place, an adequate amount of bile acid. Gallbladder surgery patients' digestion and quality of life is improved if they take bile acids with their main meals.