Role of bile acids and endotoxins in the pathogenesis and treatment of psoriasis
Author: Dr. Klára Gyurcsovics and Dr. Lóránd Bertók, Professor
Title: Role of bile acids and endotoxins in the pathogenesis and treatment of psoriasis
Source: Vitality Volume 141 Issue 17
The authors treated 551 patients with psoriasis with oral bile acids (Suprachol®, Acidum dehydrocholicum) for 1-8 weeks. The effectiveness of the treatment was assessed by the Psoriasis Area Severity Index (PASI).
Of these patients, 434 (78.8%) became asymptomatic. Of the 249 patients who received conventional treatment, only 62 (24.9%) became asymptomatic during the same period (p < 0.05).
In the acute form of psoriasis, treatment with bile acid was even more effective (95.1% symptom-free).
At two-year follow-up, 319 (57.9%) of the 551 patients treated with bile acid (acute and chronic combined) and only 15 (6.0%) of the 249 patients treated with conventional therapy were asymptomatic (p < 0.05). In acute cases, only 10 (7.2%) of the 139 patients treated with conventional therapy and 147 (79.9%) of those treated with bile acid were asymptomatic (p < 0.01) at two years.
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