Effect of bile acids on psoriasis - text

Author: Dr. István Tihanyi (physician, bibliologist, paediatrician, naturopath)

Title: Epesacids 2014

Source: https://www.nhs.uk/conditions/gallbladder-removal/

Psoriasis

The psoriasis is still one of the most common skin conditions. Hereditary factors play an important role in its development, but the importance of various infections, inflammatory processes and metabolic disorders cannot be neglected. Since bile acids prevent endotoxin translocation, they inhibit the release of cytokines that trigger inflammation. Inflammation of the small intestine reduces the production of cholecystokinin, which prevents bile secretion, thus closing the vicious circle. The low bile cannot neutralise endotoxins, which in turn further damage the intestinal tract, are absorbed and can produce the following inflammatory symptoms:
- fever
- leukocytosis
- release of cytokines (allergy, inflammation)
- elevated liver enzymes
- blood clotting disorders
- fat metabolism disorders
- symptoms of poisoning
- etc.

Any disease that causes a biliary emptying disorder or reduces the production of bile acids understandably increases the accumulation of endotoxins in the intestinal tract. Endotoxins are released into the bloodstream via the intestinal wall. Here, they are taken up by white blood cells and transported to the skin, where, after a complex inflammatory process, the body attempts to get rid of them by exfoliation. This is supported by the fact that endotoxin has been detected in the blood of psoriasis patients using a method called Limulus. Since endotoxin, as mentioned above, is the main trigger for the release of cytokines, it becomes clear how the bacterial toxin released in the intestines is involved in the development of psoriasis.