Dr. Klára Gyurcsovics and Dr. Lóránd Bertók - The role of bile acids and endotoxins in the development and treatment of psoriasis

Summary:

The authors treated 551 patients with psoriasis with oral bile acids for 1-8 weeks. The efficacy of the treatment was assessed by 'psoriasis extent and severity index'.

Of these patients, 434 (78.8%) became asymptomatic.
Of the 249 patients who received conventional treatment, only 62 (24.9%) were asymptomatic during the same period (p < 0.05).

In the acute form of psoriasis, treatment with bile acid was even more effective (95.1% symptom-free). At two-year follow-up, 319 (57.9%) of 551 patients treated with bile acid (acute and chronic combined) were asymptomatic (p < 0.05), compared to only 15 (6.0%) of 249 patients treated with conventional therapy.

In the acute cases, only 10 (7.2%) of 139 patients treated with conventional therapy and 147 (79.9%) of those treated with bile acid were asymptomatic (p < 0.01) after two years.