Protection and long-term support
Take care of your joints for comfort and everyday movement with scientifically researched ingredients!
Don't just mask the symptoms! Support your joints with ingredients that, based on research, can contribute to maintaining normal cartilage structure and joint function!
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Our Advice Line: 06-79-326-581 (Hungarian only)
Why don't traditional cartilage builders work in the long term?
For long-term cartilage protection, many buyers rely on classic glucosamine and chondroitin, while a comprehensive medical study involving thousands of people found that even in combination, these substances did not significantly reduce joint pain or slow down cartilage wear (joint space narrowing) compared to a placebo.8 Ingredients that can help maintain the normal function of cartilage and joint comfort from multiple angles may be beneficial for long-term joint support.
GALLMET Joint + Cartilage:
- Inhibits cartilage degeneration It inhibits the enzymes (MMPs) that „eat away” at healthy cartilage tissue with age.
- Supports cartilage preservation Laboratory tests confirm that Ovomet® reduces the CTX-II biomarker of cartilage degradation in the body.
- Stable rebuilding: Added copper and vitamin C support the proper formation and stabilisation of new collagen fibres.
Targeted support for processes related to cartilage integrity:
Inhibition of porcine enzymes (Ovomet®): Matrix metalloproteinase (MMP) enzymes, produced during ageing and inflammation, „devour” the collagen network that makes up cartilage. Ovomet® has been shown in studies to significantly inhibit the detrimental activity of these MMP enzymes.7, 14 In a study, biochemical tests have confirmed that taking eggshell membrane reduces markers of cartilage breakdown in urine (such as CTX-II).4, 9
Strukturális újjáépítés (Réz és C‑vitamin): Vitamin C contributes to normal collagen formation. Copper is a cofactor of the enzyme lysyl oxidase, which is involved in the formation of covalent cross-links between collagen fibres, thereby contributing to the mechanical stability of cartilage and other connective tissues.
Frequently Asked Questions
- How does eggshell membrane aid the integrity of joint cartilage?
Research using eggshell membrane has shown that the ingredient may support joint comfort, ease of movement and everyday load-bearing capacity. Studies have shown favourable results in reducing pain and stiffness, while also potentially impacting several biological processes associated with cartilage degradation.9, 14 - Matrix metalloproteinases (MMPs) are a family of enzymes that are responsible for breaking down the extracellular matrix, which is the network of proteins and other molecules that surrounds cells. MMPs play an important role in a number of physiological processes, such as wound healing and tissue remodelling. However, they can also be harmful when they are overproduced or when they are not properly regulated.When MMPs are overproduced, they can break down the extracellular matrix too quickly, which can lead to a number of problems. For example, MMPs have been implicated in the development of arthritis, cancer, and cardiovascular disease. In arthritis, MMPs can break down the cartilage that cushions the joints, leading to pain and stiffness. In cancer, MMPs can help tumours to grow and spread by breaking down the extracellular matrix that surrounds them. In cardiovascular disease, MMPs can break down the walls of blood vessels, which can lead to heart attacks and strokes.MMPs can also be harmful when they are not properly regulated. For example, some people have a genetic predisposition to overproduce MMPs, which can make them more susceptible to developing certain diseases. In addition, some drugs, such as certain chemotherapy agents, can increase MMP activity, which can further damage tissues.There are a number of ways that MMP activity can be inhibited. For example, some medications, such as tetracyclines, can inhibit MMPs. In addition, some dietary supplements, such as glucosamine and chondroitin, have been shown to have MMP-inhibiting properties.
MMPs are biological enzymes that are overproduced in the body with age or injury, and they begin to break down healthy cartilage tissue. Favourably influencing MMP activity may be important in moderating processes related to cartilage breakdown.
- Wandel S. et al., “Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis”, BMJ, 2010. https://www.bmj.com/content/341/bmj.c4675
- Ganpeng Yu et al., “Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis”, BMC, 2020. https://pmc.ncbi.nlm.nih.gov/articles/PMC7368679/
- Aguirre A. et al., “Beneficial Effects of Oral Supplementation With Ovoderm on Human Joint Connective Tissue”, J Diet Suppl., 2021. https://pmc.ncbi.nlm.nih.gov/articles/PMC9182852/
- Ruff K.J. et al., “Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee”, Clin Interv Aging, 2009. https://pmc.ncbi.nlm.nih.gov/articles/PMC2711914/
- Menghini L. et al., “Devil’s claw (Harpagophytum procumbens) and chronic inflammatory diseases”, J Ethnopharmacol., 2019. https://pmc.ncbi.nlm.nih.gov/articles/PMC8548091/
- Zhu X. et al., “Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis”, J Orthop Surg Res., 2018. https://pmc.ncbi.nlm.nih.gov/articles/PMC6035477/
- Gil-Quintana E. et al., “Eggshell Membrane: A Possible New Natural Therapeutic for Joint and Connective Tissue Disorders”, Int J Mol Sci., 2024. https://pmc.ncbi.nlm.nih.gov/articles/PMC11206400/
- Reichenbach S. et al., “Meta-analysis: chondroitin for osteoarthritis of the knee or hip”, Ann Intern Med., 2007. https://pubmed.ncbi.nlm.nih.gov/20847017/
- OVOMET® Health Efficacy Study – Pilot Study Standard, NaturalProtein. https://www.naturalprotein.cz/upload/images/other/wnda-ovomet-health-efficacy-pilot-study-standard-january15-v0.pdf
- Ovomet® – Clinical Research Data Summary – Silver Fern™ Brand. https://www.silverfernbrand.com/pages/ovomet-clinical-research-data-summary
- Efficacy of Eggshell Membrane in Knee Osteoarthritis: A Systematic Review and Meta-Analysis. https://pmc.ncbi.nlm.nih.gov/articles/PMC11356944/
- Glucosamine and chondroitin dosage recommendations – consensus academic search engine. https://consensus.app/questions/glucosamine-and-chondroitin-dosage-recommendations/
- The Truth About Glucosamine and Chondroitin Sulphate | Orthopaedic Associates of Port Huron. https://www.oaph.com/about/patient-education/patient-education-articles/truth-about-glucosamine-chondroitin-sulfate
- Eggshell Membrane: The Natural Health Powerhouse | Eggnovo. https://eggnovo.com/eggshell-a-high-potential-natural-ingredient-for-health-and-wellness/
- Safety of egg membrane hydrolysate as a novel food pursuant to Regulation (EU) 2015/2283. https://pmc.ncbi.nlm.nih.gov/articles/PMC7009436/
- The use of glucosamine and chondroitin to treat osteoarthritis: a review of the literature. https://pmc.ncbi.nlm.nih.gov/articles/PMC6565901/
- Eggshell membrane: A possible new natural therapeutic for joint and connective tissue disorders. Results from two open-label human clinical studies. https://pmc.ncbi.nlm.nih.gov/articles/PMC2697588/
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