E13 - Imunomodulačná aktivita kurkumínu

Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Download - PDF

Abstract

Although turmeric and its curcumin-enriched extracts have been used for treating arthritis, no systematic review and meta-analysis of randomized clinical trials (RCTs) have been conducted to evaluate the strength of the research. We systemically evaluated all RCTs of turmeric extracts and curcumin for treating arthritis symptoms to elucidate the efficacy of curcuma for alleviating the symptoms of arthritis.

Literature searches were conducted using 12 electronic databases, including PubMed, Embase, Cochrane Library, Korean databases, Chinese medical databases, and Indian scientific database. Search terms used were ‘‘turmeric,’’ ‘‘curcuma,’’ ‘‘curcumin,’’ ‘‘arthritis,’’ and ‘‘osteoarthritis.’’ A pain visual analogue score (PVAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were used for the major outcomes of arthritis. Initial searches yielded 29 articles, of which 8 met specific selection criteria. Three among the included RCTs reported reduction of PVAS (mean difference: -2.04 [-2.85, -1.24]) with turmeric/curcumin in comparison with placebo (P<.00001), whereas metaanalysis of four studies showed a decrease of WOMAC with turmeric/curcumin treatment (mean difference: -15.36 [-26.9, -3.77]; P=.009). Furthermore, there was no significant mean difference in PVAS between turmeric/curcumin and pain medicine in meta-analysis of five studies. Eight RCTs included in the review exhibited low to moderate risk of bias. There was no publication bias in the meta-analysis. In conclusion, these RCTs provide scientific evidence that supports the efficacy of turmeric extract (about 1000mg/day of curcumin) in the treatment of arthritis. However, the total number of RCTs included in the analysis, the total sample size, and the methodological quality of the primary studies were not sufficient to draw definitive conclusions. Thus, more rigorous and larger studies are needed to confirm the therapeutic efficacy of turmeric for arthritis.

Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003001/

gallmet.hu
sk_SKSlovenčina
Prehľad ochrany osobných údajov
gallmet.hu

Táto webová stránka používa súbory cookie, aby sme vám mohli poskytnúť čo najlepší používateľský zážitok. Informácie o súboroch cookie sa ukladajú vo vošom prehliadači a plnia funkcie, ako je rozpoznanie vás, keď sa vrátite na našu webovú lokalitu, a pomáhajú nášmu tímu pochopiť, ktoré časti webovej lokality považujete za najzaujímavejšie a najužitočnejšie.

Nevyhnutne potrebné súbory cookie

Nevyhnutne potrebný súbor cookie by mal byť vždy povolený, aby sme mohli uložiť vaše preferencie nastavenia súborov cookie.

Súbory cookie tretích strán

Táto webová stránka zhromažďuje anonymné informácie pomocou súborov cookie tretích strán (súbory cookie súvisiace s reklamou a súbory cookie týkajúce sa výkonu)